From “Desiring God” https://www.desiringgod.org/articles/will-you-wrestle-with-god

In Genesis 32, Jacob is on his way back home to Canaan with his small tribe of wives and children after a twenty year sojourn in Paddan-aram. And he is scared to death, because his estranged brother, Esau, is coming to meet him - with four hundred men (Genesis 32:6). This is no welcome party; its an army.

So after splitting his household into two camps to try and avoid complete annihilation, Jacob understandably suffering insomnia, intends to spend the night alone - no doubt in desperate prayer.

But a strange man who shows up and wrestles Jacob till daybreak rudely interrupts his plans. At some point during this weird contest Jacob realizes that he is wrestling God. And when God decides it’s time to end the match, he dislocates Jacob’s hip and demands to be released. And Jacob, in significant pain, replies, “I will not let you go unless you bless me” (Genesis 32:28).

This response clearly pleases God, who pronounces this blessing on Jacob: “Your name shall no longer be called Jacob [deceiver], but Israel [strives with God], for you have striven with God and with men, and have prevailed” (Genesis 32:28).

Jacob then limps toward his tense reunion with Esau with a weakened body and a strengthened faith. Having wrestled with God, he knows his prayers regarding Esau will be answered.

So I’ll ask again. What do you really need from God right now? What blessing do you want from him? How badly do you want it?

God will meet you in your anguish, fear, and uncertainty. But he may not meet you in the way you expect or desire. Your greatest ally may show up looking at first like your adversary, inciting you to wrestle with him.

If so, remember Jacob. There are multiple blessings in the wrestling. You may not need soft words of comfort, you may not need to be left alone with your thoughts, you may not need sleep, you may not even need a healthy hip! What you need is God’s blessing!

So when God calls you to wrestle with him in prayer, it is an invitation to receive his blessing. Stay with him and don’t give up. Do not let him go until he blesses you! He loves to bless that kind of tenacious faith and you will come out transformed.